Abnormal metabolism of secondary bile acids in patients with cirrhosis
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منابع مشابه
Abnormal metabolism of secondary bile acids in patients with cirrhosis.
The composition of bile acids in human bile was determined in bile-rich duodenal fluid on four consecutive days in a group of seven patients with cirrhosis and eight control patients with no liver disease. There was a marked reduction of secondary biliary bile acids in cirrhotic patients. Possible mechanisms for these changes are discussed.
متن کاملAbnormal metabolism of secondary bile acids in patients with cirrhosis1
The main bile acids in human bile are cholic, chenodeoxycholic, and deoxycholic with a mean ratio of 1.1:1.0:0-6 (Sjovall, 1960). Cholic and chenodeoxycholic acid are primary bile acids synthesized from cholesterol in the liver (Bergstrom, Danielsson, and Samuelsson, 1960). These bile acids are not interconvertible. The secondary bile acids, deoxycholic and lithocholic, are products formed by t...
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Alcohol abuse with/without cirrhosis is associated with an impaired gut barrier and inflammation. Gut microbiota can transform primary bile acids (BA) to secondary BAs, which can adversely impact the gut barrier. The purpose of this study was to define the effect of active alcohol intake on fecal BA levels and ileal and colonic inflammation in cirrhosis. Five age-matched groups {two noncirrhoti...
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Serum bile acid classes have been studied in 15 patients with primary biliary cirrhosis in five patients with cholestasis, and in five patients who had cirrhosis without cholestatic features. Conjugated monohydroxy bile acids (12-35% serum total bile acids) were found in eight of 11 sera from patients with primary biliary cirrhosis, in sera from four patients with cholestasis but not in any of ...
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ژورنال
عنوان ژورنال: Gut
سال: 1970
ISSN: 0017-5749
DOI: 10.1136/gut.11.5.420